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Updated: Jul 22, 2025

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
10:51

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists

Published on: November 15, 2013

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UBR5在染色质上形成依赖于连接体的复合体,以调节核激素受体的稳定性

Jonathan M Tsai1, Jacob D Aguirre2, Yen-Der Li3

  • 1Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Division of Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Molecular cell
|July 21, 2023
PubMed
概括

无素结合酶UBR5在激动剂结合后降解多个核激素受体 (NR),这是癌症治疗中至关重要的过程. 这一发现揭示了UBR5作为NR介导转录的关键调节者.

关键词:
在HECT-E3连接酶的作用下,核受体是一种核受体.蛋白质降解 蛋白质降解结构生物学结构生物学无处不在的素连接酶.

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