Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Regulation of Expression at Multiple Steps01:23

Regulation of Expression at Multiple Steps

944
The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the...
944
Regulation of Expression Occurs at Multiple Steps02:24

Regulation of Expression Occurs at Multiple Steps

3.1K
3.1K
Constitutive and Regulated Gene Expression01:27

Constitutive and Regulated Gene Expression

42
Gene expression in prokaryotes is governed by constitutive and regulated systems, allowing cells to balance the production of essential proteins with adaptive responses to environmental changes.Constitutive Gene ExpressionConstitutive, or housekeeping, genes are continuously expressed as they encode proteins vital for fundamental cellular processes. These include enzymes for glycolysis, ribosomal components for protein synthesis, and proteins involved in DNA replication. Their constant...
42
Combinatorial Gene Control02:33

Combinatorial Gene Control

8.4K
Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
8.4K
Genetic Screens02:46

Genetic Screens

5.0K
Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
5.0K
Cell Specific Gene Expression01:58

Cell Specific Gene Expression

4.7K
4.7K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Metabolite glues as a means of purine sensing and chemotherapeutic response.

Nature·2026
Same author

Systemic degradation of repressive transcription factors gates gene expression and cell fate specification.

bioRxiv : the preprint server for biology·2026
Same author

Structural Transformation of a BRAF Inhibitor into a Selective PKR Inhibitor.

Journal of medicinal chemistry·2026
Same author

A Scoping Review on Strategies for Navigating Conflicting Rights Between Safety and Autonomy in Residential Long-Term Care in the United States.

Journal of the American Geriatrics Society·2026
Same author

Dataset development and performance analysis of a specialized conversational artificial intelligence model for targeted smoking cessation dialogues.

Health education research·2026
Same author

Localized heme sensing through a ternary molecular glue.

bioRxiv : the preprint server for biology·2026

相关实验视频

Updated: Jul 22, 2025

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline
10:44

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline

Published on: December 7, 2021

2.2K

孤儿质量控制模式 网络动态和基因表达

Kevin G Mark1, SriDurgaDevi Kolla1, Jacob D Aguirre2

  • 1Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA, USA.

Cell
|July 21, 2023
PubMed
概括

E3链酶UBR5降解未配对的转录因子,建立动态蛋白质网络,对细胞命运决定和基因表达至关重要. 这种孤儿质量控制机制维持了细胞对环境信号的响应.

关键词:
标签: 其他其他国家一个UBR5有分支的泛素链孤儿质量控制蛋白质组干细胞转录因子无处不在的

更多相关视频

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis
09:58

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis

Published on: June 27, 2020

2.8K
A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations
09:34

A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations

Published on: October 25, 2018

6.7K

相关实验视频

Last Updated: Jul 22, 2025

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline
10:44

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline

Published on: December 7, 2021

2.2K
Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis
09:58

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis

Published on: June 27, 2020

2.8K
A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations
09:34

A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations

Published on: October 25, 2018

6.7K

科学领域:

  • 分子生物学
  • 细胞信号传输
  • 蛋白质降解途径

背景情况:

  • 细胞依赖复杂的蛋白质网络来决定细胞命运.
  • 这些网络中的功能障碍蛋白相互作用与各种疾病有关.
  • 管理这些网络的组成和动态的机制尚未完全理解.

研究的目的:

  • 确定调节转录监管网络的组成和动态的信号枢纽.
  • 研究E3连接酶UBR5在蛋白质网络稳态中的作用.
  • 了解蛋白质降解如何促进动态基因表达.

主要方法:

  • 生物化学测试以描述蛋白质与蛋白质的相互作用.
  • 结构分析以确定绑定接口.
  • 研究UBR5在调节转录调节剂中的作用,包括与c-Myc相关的调节剂.

主要成果:

  • UBR5被确定为一种降解转录调节器未配对子单元的信号枢纽.
  • 只有在复杂解离后,UBR5才能与特定的图案结合.
  • 通过UBR5快速转换未配对的子单元促进了动态蛋白相互作用.

结论:

  • 通过UBR5进行的孤儿质量控制对于建立动态蛋白质网络至关重要.
  • 这一过程使细胞能够平衡基因表达与环境反应.
  • 了解UBR5的作用为与异常基因表达相关的疾病提供了潜在的治疗策略.