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检查医学生是否携带多药耐药病原体?
E Smelikova1, P Drevinek2, O Nyc2
1Department of Medical Microbiology, 2(nd) Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic; Department of Genetics and Microbiology, Faculty of Science, Charles University, Prague, Czech Republic.
The Journal of hospital infection
|July 21, 2023
概括
医学学生携带多种耐药性病原体,鼻腔携带金黄色葡萄球菌与生活方式因素有关. 早期检测和卫生意识对于防止耐药菌株传播至关重要.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 医学学生中多药耐药 (MDR) 病原体携带的研究不足.
- 医学学生对患者和医院环境的接触增加,造成病原体传播的风险.
研究的目的:
- 调查医学学生中MDR病原体的肠道和鼻腔携带.
- 分析MDR病原体携带与学生生活方式和人口统计数据之间的关联.
主要方法:
- 2021年招聘第一年级和最后一年级医学学生.
- 使用直肠和鼻检测产生ESBL,耐科里斯,tigecycline或carbapenem的格拉姆阴性细菌,耐菌素的肠球菌和金黄色葡萄球菌.
- 通过spa类型和全基因组测序来对耐药的Gram-阴性分离物和MRSA进行S. aureus分离物的表征.
主要成果:
- 44.9%的学生 (80/178) 鼻腔携带金黄色细菌;2个分离物是MRSA.
- 检测到7种产生ESBL的菌株和16种对胆固醇抗性细菌的实例.
- 黄金菌鼻携带与抗生素/益生菌使用相反相关;在与牲畜接触的学生中,黄金菌和抗素细菌的携带率更高.
结论:
- 医学学生拥有 (多) 耐药细菌,第一年级和最后一年级学生之间没有显著差异.
- 学生自我查提高了对殖民和传播风险的认识,特别是在手部卫生方面.
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