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精神活性物质25H-NBOMe和25H-NBOH在雄性大鼠中诱导类似抗抑郁药的行为

Barbara G Ferri¹, Cintia O de Novais¹, Raquel S Bonani²

¹Programa de Pós-Graduação Multicêntrico Em Ciências Fisiológicas (PPGMCF), Universidade Federal de Alfenas (Unifal-MG), Alfenas, MG, Brazil.

European journal of pharmacology

|July 21, 2023

概括

这项研究研究了25H-NBOMe和25H-NBOH在老鼠中的抗抑郁作用. 这两种迷幻物质都表现出抗抑郁药的特性,这表明在实验精神病学中具有潜在的治疗应用.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
药理学药理学是指药理学的学科.

背景情况:

众所周知,环替代型乙烯胺通过5-基二胺2 (5-HT2A) 受体相互作用诱导幻觉效应.
心理药物对心理健康状况的治疗潜力是一个越来越有研究兴趣的领域.

研究的目的:

为了评估25H-NBOMe和25H-NBOH对成年雄性大鼠抑郁症行为的影响.
评估这些新型迷幻化合物的幻觉性质,运动运动活性和抗抑郁药物潜力.

主要方法:

成年雄性Wistar大鼠被给予25H-NBOMe和25H-NBOH的25H-NBOMe和25H-NBOH的25H-NBOMe和25H-NBOH的25H-NBOMe/kg的剂量.
用头反应测试 (HTR) 测量了幻觉效应.
分别通过开放场测试 (OFT) 和强迫游泳测试 (FST) 评估了运动运动活动和类似抑郁的行为.

主要成果:

所有测试的25H-NBOMe和25H-NBOH剂量都诱导了幻觉效应,由HTR证实.
这两种物质都显著增加了在FST中逃跑的动机,表明了类似抗抑郁药的效果.
除了最高剂量 (3 mg/kg) 之外,OFT中的运动运动活动没有受到影响,这减少了运动.

结论:

一次剂量25H-NBOMe和25H-NBOH在老鼠模型中表现出显著的抗抑郁药物特性.
这些发现为这些迷幻物质在治疗抑郁症方面的潜在治疗应用提供了新的见解.
实验精神病学的进一步研究可能会探索这些化合物,以开发在迷幻疗法中有效的临床实践.

关键词:

抑郁症抑郁症抑郁症强制游泳测试强制游泳测试头部推文响应测试测试迷幻药物迷幻药物是一种精神药物.

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