快速溶解的电纳米纤维用于阴道内输送抗生素或益生菌
Farnaz Minooei1, Nicole M Gilbert2, Longyun Zhang3
1Department of Chemical Engineering, University of Louisville Speed School of Engineering, Louisville, KY 40202, USA.
概括
新的电纤维为抗生素和益生菌提供了一种新的阴道输送系统. 这项技术有效治疗感染并殖民阴道,为生殖尿路健康提供了一个有希望的替代方案.
科学领域:
- 生物材料科学 生物材料科学
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 阴道感染需要先进的抗生素和益生菌的输送系统.
- 目前的治疗方法在有效性和患者遵守方面面临挑战.
- 电纤维为局部性阴道药物和益生菌输送提供了潜在的解决方案.
研究的目的:
- 开发和评估快速溶解的电聚乙烯氧化物 (PEO) 纤维,用于通过阴道输送甲化物和Lactobacillus acidophilus.
- 评估这些纤维在治疗细菌性阴道炎和建立益生菌殖民的体外和体内疗效.
主要方法:
- 带有甲基醇或Lactobacillus acidophilus的PEO纤维的电.
- 在体外评估使用共同培养和阴道上皮细胞对加德内瑞拉菌的细菌抑制.
- 在小鼠阴道殖民模式中的体内评估,以评估安全性和殖民效果.
主要成果:
- PEO纤维没有对阴道粘膜或促进加德内拉菌生长产生不良影响.
- 含有美特罗尼达的纤维在体内显著减少了加德内雷拉感染.
- 含有 Lactobacillus acidophilus 的纤维在体外有效抑制了 Gardnerella,并在体内实现了与自由益生菌相比较的阴道殖民.
结论:
- 快速溶解的电PEO纤维是通过阴道输送抗生素和益生菌的可行平台.
- 这项技术在治疗生殖尿路感染和保持阴道健康方面表现有前途.
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