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基于Pullulan的含有西尔代纳菲尔的口溶性薄膜的电

Elisabetta Ravasi¹, Alice Melocchi², Alessia Arrigoni¹

¹Dipartimento di Chimica, Materiali e Ingegneria Chimica "G. Natta", Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milano, Italy.

International journal of pharmaceutics

|July 21, 2023

概括

电成功地为儿科肺高血压制造了快速溶解的西尔代纳菲尔口溶膜 (ODF). 这些纳米结构薄膜提供快速分解和改善药物的生物可用性,可能降低所需剂量.

科学领域:

制药技术制药技术制药技术
材料科学材料科学材料科学
纳米技术纳米技术

背景情况:

儿科患者的肺动脉压管理需要有效的药物输送系统.
西尔德纳菲尔是一种潜在的治疗药物,但其口服生物可用性可能是一个限制.
口腔可分散膜 (ODF) 为儿科药物管理提供了一个有前途的替代方案.

研究的目的:

评估用于制造含有西迪纳菲尔的ODF的电的可行性.
优化电旋转参数,以生产无缺陷的纳米结构薄膜.
与其他片制作方法相比,评估电ODF的性能.

主要方法:

聚合物溶液 (pullulan 和 sildenafil) 的系统性表征,包括粘度和表面张力.
优化电参数,以实现纳米范围纤维的连续高速生产.
综合评估膜形态,微观结构,药物含量,固态特性和流体相互作用.
与螺旋和刀片涂层薄膜进行比较分析.

主要成果:

电产生无缺陷,大小均的纳米结构纤维.
电ODF表现出最快的分解时间 (在几秒内),符合药库标准.
这些片段显示了提升西尔德纳菲尔生物可用性的潜力.
纤维纳米结构显著影响了ODF性能.

结论:

电是一种可行的方法,用于生产带有西尔德纳菲尔的ODF,并迅速分解.
纳米结构的薄膜显示了改善儿童患者的西尔代纳菲尔输送的前景.
由于生物可用性增加,这种方法可能使西尔德纳菲尔剂量降低.

关键词:

药物交付是药物交付的过程.快速溶解的快速溶解的绿色制药公司绿色制药公司纳米纤维纳米纤维是一种自然聚合物的天然聚合物.儿科患者儿科患者类风病学类风病学类风病学

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