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在瘤微环境中介的NIR-I到NIR-II转换Au自组装用于theranostics

Mengxin Wang¹, Xue Zhang¹, Qian Chang¹

¹Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, The Key Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, International Joint Laboratory of Resource Chemistry, Shanghai Normal University, Shanghai 200234, China.

Acta biomaterialia

|July 21, 2023

概括

一个新的策略使用瘤微环境激活的黄金自组装从近红外I到NIR-II成像. 这提高了深层瘤诊断的准确性,并使得有针对性的光热疗法成为可能,克服了目前的局限性.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
在瘤学瘤学.

背景情况:

用于瘤治疗的光热剂面临着有限的透深度和对健康组织的损伤的挑战.
现有的近红外I (NIR-I) 剂总是"开启",导致诊断不准确和不分青红白的治疗.

研究的目的:

开发一种瘤微环境 (TME) 激活的策略,将光热剂从NIR-I区域切换到NIR-II区域.
通过利用TME介导的黄金自组装来提高深层瘤诊断的准确性,并实现选择性光热疗法.

主要方法:

作为模型光热剂,采用了化物伊米达酸框架-8 (ZIF-8) 涂层金纳米棒 (AuNRs@ZIF-8).
在TME中研究了ZIF-8解离后从NIR-I到NIR-II的信号转换.
评估了TME激活的NIR-II光热疗法在抑制瘤生长方面的疗效.

主要成果:

在正常组织中,由于ZIF-8阻止AuNR聚合,只检测到NIR-I光声成像信号.
在TME中,ZIF-8解离导致AuNR聚合,激活NIR-II成像和减弱NIR-I信号以准确可视化瘤.
由TME激活的NIR-II光热疗法显示出显著的瘤生长抑制.

结论:

开发的TME激活的NIR-I到NIR-II切换策略可以提高深度瘤诊断的准确性.
这种方法通过允许选择性光热疗法来最大限度地减少对正常组织的损伤.
这项工作提出了一种创新策略,用于创建TME激活的NIR-II智能光热剂,以改善瘤治疗学.

关键词:

黄金纳米棒是一种金的纳米棒.接近-II 接近-II 照片声学成像成像技术光热疗法是一种光热疗法.瘤微环境是一个微环境.

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