在第二个三个月内用BNT162b2 mRNA疫苗对母亲进行免疫接种,可诱导人乳中强烈的IgA反应:一项前性队列研究
Aya Kigel1, Sharon Vanetik2, Laurence Mangel3
1The Shmunis School of Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel; The Center for Combating Pandemics, Tel Aviv University, Tel Aviv, Israel.
The American journal of clinical nutrition
|July 21, 2023
概括
在怀孕期间用BNT162b2 mRNA疫苗免疫母亲可以通过母乳抗体增强婴儿的保护. 在怀孕第二个三个月内接种疫苗可以最大限度地提高成熟牛奶中的IgA水平,从而增强婴儿免疫力.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 哺乳期生物学 哺乳期生物学
背景情况:
- 用BNT162b2 mRNA疫苗对母亲进行免疫接种对于婴儿的保护至关重要.
- 了解不同哺乳期不同阶段在母乳中的疫苗特异性抗体反应是有限的.
- 孕产妇疫苗接种时间对母乳中的抗体水平的影响需要进一步调查.
研究的目的:
- 在母乳BNT162b2 mRNA接种疫苗后,评估母乳乳中的IgG,IgA和IgM抗体反应.
- 确定怀孕期间母体免疫的最佳时间,以最大限度地提高母乳中的保护性抗体水平.
主要方法:
- 一项前性队列研究包括62名在怀孕期间 (第二或第三季度) 用BNT162b2 mRNA疫苗接种疫苗的哺乳期妇女.
- 在各种哺乳期收集了149个母乳样本.
- 统计比较与16个来自大流行前对照组的样本进行了统计比较.
主要成果:
- 与成熟的牛奶相比,乳酪显示出IgG,IgA和IgM的水平显著更高.
- 母亲免疫接种时间影响了抗体水平:第二个月的疫苗接种在成熟的牛奶中产生了更高的IgA.
- 与第二个三个月的疫苗接种相比,第三个月的疫苗接种导致成熟牛奶中的IgG水平更高.
结论:
- 用BNT162b2 mRNA疫苗在第二个三个月内对母亲进行免疫接种,可以在哺乳期间提高母乳中的疫苗特异性IgA水平.
- 鉴于IgA在粘膜免疫中的作用,建议在第二个三个月内接种疫苗,以获得最佳的婴儿保护.
- 这项研究提供了支持母体疫苗接种特定时间的证据,以最大限度地将抗体转移到婴儿身上.
关键词:
BNT162b2 mRNA疫苗的使用情况在 COVID-19 疫情中,对抗体反应的反应母乳 母乳是母乳中的一种.人类牛奶是人类的牛奶.婴儿 婴儿 婴儿 婴儿孕产妇免疫接种方式怀孕 怀孕 怀孕 怀孕 怀孕通过分泌的IgAA.通过细胞转化 (transcytosis).更多相关视频
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