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来自Naematelia aurantialba的多糖体NAP-3:结构特征和辅助的低血糖活性
Lu Sun1, Jiang Jiang1, Tao Jing1
1Department of Food Quality and Safety, National R&D Center for Chinese Herbal Medicine Processing, College of Engineering, China Pharmaceutical University, Nanjing 211198, China.
Carbohydrate polymers
|July 21, 2023
概括
来自Naematelia aurantialba的一种新型多糖化物 (NAP-3) 显示出强大的抗糖尿病作用. 与甲福明相结合,NAP-3显著降低血糖,并改善糖尿病小鼠的胰岛素敏感性.
科学领域:
- 自然产品化学 自然产品化学
- 药理学 药理学是指药理学的学科.
- 生物化学 生物化学
背景情况:
- 糖尿病是一种全球性健康问题,需要新的治疗策略.
- 来自药用真菌的多糖因其健康益处而受到越来越多的研究.
- 纳马特利阿乌兰蒂阿尔巴是一种传统的药用,具有尚未开发的治疗潜力.
研究的目的:
- 来自Naematelia aurantialba.的新型多糖体 (NAP-3) 的分离和特征.
- 评估NAP-3的体外酶抑制和体内抗糖尿病作用.
- 为了研究NAP-3作为一种辅助疗法与甲福林用于糖尿病治疗.
主要方法:
- 提取和净化NAP-3的水.
- 使用FT-IR,HPLC,GC-MS和NMR进行结构阐明.
- 在体外测定α-葡萄糖酶和α-氨基酶抑制.
- 在HFD/STZ诱导的糖尿病小鼠和胰岛素抵抗HepG2细胞的体内研究.
主要成果:
- NAP-3是一种均的多糖 (428 kDa),由特定的单糖组成.
- NAP-3显示出显著的α-葡萄糖酶和α-氨基酶抑制活性.
- 在糖尿病小鼠中,NAP-3和甲福明的联合治疗显示出优异的低血糖效应.
- 在HepG2细胞中,NAP-3增强了葡萄糖吸收和减少了氧化应激.
结论:
- NAP-3具有强大的抗糖尿病特性.
- NAP-3作为甲胺的有效辅助剂,改善血糖控制和胰岛素敏感性.
- 这项研究强调了Naematelia aurantialba多糖的治疗潜力,用于糖尿病管理.
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