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血液内皮过渡和表型可塑性:在对缺血反应中,是完整性/通透性的关键调节者

Nicolas Bréchot¹, Alexandre Rutault², Iris Marangon²

¹Center for Interdisciplinary Research in Biology, College de France, Centre national de la recherche scientifique, Institut national de la santé et de la recherche médicale, Université PSL, Paris, France; Intensive Care Medicine Department, Université de Paris Cité, Hôpital européen Georges-Pompidou, AP-HP, AP-HP.CUP, 75015 Paris, France.

Seminars in cell & developmental biology

|July 21, 2023

概括

内皮细胞 (ECs) 维护组织健康,调节血管的透性. 了解EC如何对缺血反应对于开发针对血管泄漏的新疗法至关重要.

科学领域:

心血管生物学心血管生物学
细胞生物学细胞生物学
生理学生理学生理学

背景情况:

血液内皮细胞 (ECs) 对于组织平衡,再生和调节血管功能,如透性至关重要.
通过基因表达,ECs表现出异质性,并通过基因表达适应环境变化.
缺血严重影响内皮细胞,使缺血诱导的血管完整性调节对健康至关重要.

研究的目的:

审查控制内皮细胞维护的刺激和分子机制.
探索内皮细胞在调节毛细血管泄漏中的表型可塑性.
确定血管透性障碍的潜在治疗策略.

主要方法:

文献综述侧重于内皮细胞生物学和血管透性.
对内皮细胞对缺血状况的反应背后的分子机制的分析.
综合影响内皮细胞表型和功能的刺激信息.

主要成果:

内皮细胞在维持血管完整性和调节液体外流方面发挥着核心作用.
缺血会对内皮产生有害影响,这凸显了血管完整性的重要性.
内皮细胞的可塑性是控制毛细血管泄漏的关键因素.

结论:

了解内皮细胞的维护和可塑性对于解决缺血引起的血管功能障碍至关重要.
控制EC行为的分子机制为控制毛细血管泄漏提供了潜在的治疗点.
对EC对环境变化反应的进一步研究可能会导致器官功能障碍的新治疗方法.

关键词:

细胞命运细胞命运细胞的可塑性细胞的可塑性内皮质的完整性内皮质的完整性缺血缺血是因为缺血.透性透性的

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