相关实验视频

Updated: Jul 22, 2025

Eye Tracking, Cortisol, and a Sleep vs. Wake Consolidation Delay: Combining Methods to Uncover an Interactive Effect of Sleep and Cortisol on Memory

Eye Tracking, Cortisol, and a Sleep vs. Wake Consolidation Delay: Combining Methods to Uncover an Interactive Effect of Sleep and Cortisol on Memory

Published on: June 18, 2014

皮质醇唤醒反应作为电治疗的认知副作用的生物标志物

Thomas C Feenstra¹, Eldon K J la Cruz², Jasmien Obbels³

¹GGZ Centraal Mental Health Care (TCF, EKJLC, DR), Amersfoort, The Netherlands; Amsterdam Public Health Research Institute, Mental Health Program (TCF, ATFB, DR), Amsterdam, The Netherlands.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

|July 21, 2023

概括

皮质醇唤醒反应 (CAR) 似乎不是可靠的生物标志物,用于跟踪接受电疗法 (ECT) 的老年人认知衰退. 建议在更大的患者群体进行进一步的研究.

科学领域:

神经科学是一个神经科学.
内分泌学在内分泌学.
精神病学是一个精神病学.

背景情况:

电疗法 (ECT) 是一种治疗严重抑郁症的方法.
认知副作用,包括衰退,可以在ECT期间发生.
皮质醇唤醒反应 (CAR) 是白天皮质醇波动,可能与压力和认知功能有关.

研究的目的:

研究皮质醇唤醒反应 (CAR) 作为接受电治疗 (ECT) 的患者认知衰退的生物标志物的潜力.

主要方法:

研究了一组50名接受ECT的抑郁症老年患者队列.
认知变化被评估使用迷你精神状态检查 (MMSE) 在ECT前后的得分.
线性回归分析检查了CAR (以曲线下的面积计量) 与MMSE得分变化之间的关联,并对混因素进行了调整.

主要成果:

在ECT过程中,在CAR和认知变化之间没有发现统计学意义上的关联.
调整和未调整的模型都无法证明CAR和ECT引起的认知衰退之间的联系.

结论:

皮质醇唤醒反应 (CAR) 不是预测或监测ECT相关认知衰退的合适生物标志物.
未来的研究需要更大的样本大小来最终评估CAR在ECT认知影响中的作用.

关键词:

大型抑郁症主要是抑郁症.认知方面的副作用.皮质醇是一种皮质醇.电疗法是一种电疗法.

更多相关视频

Pupillary Response as Assessment of Effective Seizure Induction by Electroconvulsive Therapy

Pupillary Response as Assessment of Effective Seizure Induction by Electroconvulsive Therapy

Published on: April 11, 2019

Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment

Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment

Published on: July 7, 2023

相关概念视频

Electroconvulsive Therapy

Electroconvulsive Therapy

Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early...