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对于目前流通的Omicron亚型的受体结合和更广泛的跨物种受体识别的结构基础

Zhennan Zhao1,2, Yufeng Xie1,3, Bin Bai1,2

  • 1CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.

Nature communications
|July 21, 2023
PubMed
概括

新的SARS-CoV-2 Omicron亚型,包括BA.5,显示出有关受体结合的迹象. 一种特定的突变 (R493Q) 增加了与人类和动物ACE2的结合亲和力,增加了跨物种传播风险.

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