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预期T1映射评估在内加多布托罗尔后大脑中的加多保留
Geir Ringstad1,2, Lars Magnus Valnes3, Svein Are Sirirud Vatnehol4,5
1Department of Radiology, Oslo University Hospital- Rikshospitalet, Oslo, Norway.
Neuroradiology
|July 21, 2023
概括
静脉内对比剂施用后4周内没有检测到大脑中的加多保留. 这表明大脑脊髓液中对比剂的存在对大脑加多积累的影响最小.
科学领域:
- 神经辐射学神经辐射学
- 神经成像是一种神经成像.
- 药理动力学 药理动力学
背景情况:
- 在MRI中使用基于加多的对比剂 (GBCA).
- 人们对大脑中加多的保留存在担忧.
- 内注射提供了直接通往脑脊液 (CSF) 的途径.
研究的目的:
- 为了研究在导管内注射后大脑中的加多保留.
- 在注射后4周评估大脑组织中加多的积累.
- 评估CSF对比性泄漏在大脑保留中的作用.
主要方法:
- 涉及76名参与者进行的前性研究,这些参与者接受了内加多布托罗尔 (0.5毫米).
- 在对比剂给药前和4周后进行的标准化大脑T1映射.
- 统计分析包括对对比,T1变化的安全率为3%.
主要成果:
- 在大脑皮层或基底腺节中没有检测到显著的加多保留.
- 观察到白质T1放松时间的轻微,统计学上显著的减少 (0.98%),在安全边际内.
- 后腔结构显示出不良对齐,排除了对大脑干和小脑的评估.
结论:
- 内加多布托罗尔没有导致大脑半球中可检测到的加多保留.
- 脑组织中加多的积累在静脉内对比剂的使用后似乎很小.
- 对比性泄漏到脑液的途径可能不是大脑加多保留的主要驱动因素.
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