相关实验视频

Updated: Jul 22, 2025

Generation of Native, Untagged Huntingtin Exon1 Monomer and Fibrils Using a SUMO Fusion Strategy
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Generation of Native, Untagged Huntingtin Exon1 Monomer and Fibrils Using a SUMO Fusion Strategy

Published on: June 27, 2018

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粉样蛋白修饰剂SERF1a通过螺旋相互作用与多Q扩展的亨廷丁-外子1相互作用,并加剧了多Q诱导的毒性

Tien-Ying Tsai1,2,3, Chun-Yu Chen1, Tien-Wei Lin1

  • 1Genomics Research Center, Academia Sinica, 128, Academia Rd., Sec. 2, Nankang District, Taipei, 115, Taiwan.

Communications biology
|July 21, 2023
PubMed
概括

粉样蛋白修饰剂SERF1a增强了亨廷顿病 (HD) 的蛋白质聚合和毒性. 这项研究揭示了SERF1a的分子机制,为HD提供了潜在的治疗点.

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Fractionation for Resolution of Soluble and Insoluble Huntingtin Species

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Efficient and Scalable Production of Full-length Human Huntingtin Variants in Mammalian Cells using a Transient Expression System

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相关概念视频

Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
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