肠道健康和肠道疾病中的共体真菌
Kyla S Ost1, June L Round2,3
1Department of Immunology and Microbiology, University of Colorado Anschutz School of Medicine, Aurora, CO, USA. kyla.ost@cuanschutz.edu.
Nature reviews. Gastroenterology & hepatology
|July 21, 2023
概括
肠道菌群,或真菌群体,在肠道健康和疾病中起着关键作用. 了解真菌的作用和相互作用为肠道疾病提供了新的治疗途径.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 肠道微生物群影响哺乳动物的发育,消化和疾病.
- 研究主要集中在细菌上,但共生真菌 (菌群) 的作用正在获得认可.
- 虽然真菌的数量比细菌少,但它们构成了重要的生物质,并拥有独特的真核生物代谢途径.
研究的目的:
- 审查证据,将特定的真菌生物群成员与肠道疾病联系起来.
- 要突出肠道真菌,细菌和宿主免疫系统之间的相互作用.
- 探索肠道真菌的有害和有益作用及其治疗潜力.
主要方法:
- 关于肠道菌群和肠道疾病的研究文献综述.
- 对真菌-细菌和真菌-免疫相互作用的研究分析.
- 关于真菌对炎症性肠道疾病,结直肠癌和胰腺癌的影响的综合证据.
主要成果:
- 特定的真菌物种涉及到各种肠道疾病的发病.
- 真菌群体与细菌群体和宿主免疫系统有显著的相互作用.
- 已经确定了肠道真菌的致病作用和有益作用.
结论:
- 肠道菌群是肠道健康和疾病的关键因素.
- 向真菌及其相互作用为胃肠道疾病提供了有前途的治疗策略.
- 对菌群的进一步研究对于开发新型治疗方法至关重要.
更多相关视频
相关概念视频
Overview of Fungi
56
Fungi are a diverse group of eukaryotes more closely related to animals than other eukaryotes. Fungal cell walls comprise chitin, a polysaccharide that provides structural strength, and glucans, which contribute to flexibility and integrity. Other polysaccharides, such as mannans and galactosans, may supplement or replace chitin in some fungi. These adaptations, along with their preference for acidic environments and tolerance for high osmotic pressure, enable fungi to thrive in various...
56
The Roles of Bacteria and Fungi in Plant Nutrition
36.2K
Plants have the impressive ability to create their own food through photosynthesis. However, plants often require assistance from organisms in the soil to acquire the nutrients they need to function correctly. Both bacteria and fungi have evolved symbiotic relationships with plants that help the species to thrive in a wide variety of environments.
36.2K
Bacterial Flora of the Large Intestine
522
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
522
Fungal Phylum Microsporidia
41
Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
41
Fungal Group Zygomycota
43
Zygomycota, previously classified as a distinct fungal group, are primarily terrestrial, saprophytic molds that play a crucial role as decomposers. Recent phylogenetic studies have revealed that these fungi are now divided into two major clades — Mucoromycota, which includes many symbiotic species, and Zoopagomycota, which primarily consists of parasitic and pathogenic fungi. These groups exhibit distinct ecological roles and reproductive strategies while sharing key structural and...
43
Defense Mechanism Against Infection
6.7K
Natural flora, body system defenses, and inflammation are natural barriers of the body against infectious agents regardless of previous exposure. Normal floras of the human body refer to the microbial population that colonizes the skin and mucous membranes.
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
6.7K


