新兴的RORγt+抗原呈现细胞家族
Jakub Abramson1, Jan Dobeš2, Mengze Lyu3,4,5
1Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel. jakub.abramson@weizmann.ac.il.
Nature reviews. Immunology
|July 21, 2023
概括
发现了一种表达视网膜酸受体相关孤儿受体-γt (RORγt) 的抗原呈现细胞 (APC) 的新家族. 这些RORγt+ APC在免疫,炎症和宿主微生物相互作用中起着至关重要的作用.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
背景情况:
- 抗原呈现细胞 (APC) 对T细胞相互作用和免疫反应调节至关重要.
- 各种细胞类型,包括传统的树突细胞,B细胞和巨细胞,作为专业的APC发挥作用.
- 在诸如胸膜上皮细胞,内皮细胞和粒细胞等细胞中观察到非经典的抗原呈现作用.
研究的目的:
- 总结一下一个新发现的RORγt+ APC家族的发现和功能.
- 讨论这些细胞在免疫,炎症和耐受性方面的影响.
- 突出这一新兴领域的知识差距和未来研究方向.
主要方法:
- 文献综述和对RORγt+ APC的最新发现的综合.
- 对确定RORγt作为新型APC子集标志物的研究进行分析.
- 整合有关这些细胞在各种免疫环境中的功能作用的数据.
主要成果:
- 鉴定了一种新型APC家族,其特征是转录因子RORγt.
- RORγt+ APCs,包括3组先天性淋巴细胞和异位性自身免疫调节器表达细胞,是免疫的关键调节者.
- 这些细胞显著影响炎症和耐受性,特别是在宿主微生物相互作用中.
结论:
- 发现RORγt+ APCs在了解免疫调节方面取得了重大进展.
- 需要进一步的研究来解决当前报告中的差异,并充分阐明这些细胞的功能.
- 这一领域对推进基本免疫学和开发新的治疗策略具有前景.
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