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在多个横截面研究中,遗传标记和高血压控制之间没有关联
Valeriya Chekanova1, Julien Vaucher2, Pedro Marques-Vidal3
1National Medical Research Center of Cardiology, Moscow, Russia.
Scientific reports
|July 21, 2023
概括
在瑞士,遗传标记似乎没有影响高血压控制. 这项研究发现,整体高血压管理不佳,年龄是唯一重要的因素,而不是遗传风险得分或个人SNP.
科学领域:
- 心血管遗传学 心血管遗传学
- 药物基因组学 药物基因组学
- 公共卫生 公共卫生
背景情况:
- 在全球范围内,高血压控制仍然是一个重大的公共卫生挑战.
- 遗传因素越来越多地被调查,以确定它们在高血压管理和治疗反应中的潜在作用.
- 了解遗传关联可以个性化抗高血压药物选择并改善患者的治疗结果.
研究的目的:
- 研究瑞士人口中遗传标记和高血压控制之间的关联.
- 评估基因风险评分 (GRS) 和单个单核酸多态 (SNP) 在预测高血压控制中的有用性.
- 根据欧洲心脏病学会 (ESC) 的指导方针,评估受控高血压的患病率.
主要方法:
- 在瑞士洛桑进行的两项横截面调查,分别包括1073名高血压患者和1157名高血压患者.
- 使用ESC指南评估的高血压控制,值为140/90 mmHg和130/80 mmHg.
- 分析包括18-SNP高血压遗传风险评分 (GRS) 和133个与抗高血压药物反应相关的SNP.
主要成果:
- 在所有调查中,受控高血压的患病率分别为58.8%和63.6% (140/90 mmHg值).
- 在140/90或130/80毫米的值下,GRS和高血压控制之间没有发现显著的关联.
- 单个SNP和GRS没有显示与高血压控制有一致的关联;年龄较大与负相关.
结论:
- 在研究的瑞士人群中,高血压控制不够理想.
- 遗传标记,包括GRS和单个SNP,在这个队列中与高血压控制无关.
- 当前的遗传风险得分可能不是高血压控制的有效预测指标.
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