构建时间不变的动态监控规则,以实现最佳的监控时间表
Xinyuan Dong1, Yingye Zheng2, Daniel W Lin2,3
1Amazon.com, Inc, Seattle, Washington, USA.
Biometrics
|July 21, 2023
概括
本研究引入了动态监测规则 (DSR) 的新方法,以优化患者监测时间表,随着时间的推移平衡收益和成本. 这项研究提供了最佳的时间不变的DSR,以改善临床决策.
科学领域:
- 生物统计学 生物统计学
- 临床试验设计 临床试验设计
- 医疗保健服务研究 医疗服务研究
背景情况:
- 动态监测规则 (DSR) 是临床实践中的适应性监测策略.
- 当前的DSR通常需要时间变化的参数,使实现复杂化.
- 需要时间不变的DSR来平衡临床效益和成本.
研究的目的:
- 建议为动态监控规则 (DSR) 提出一个新的标准,考虑利益与成本的权衡.
- 开发和验证用于估计最佳时间不变DSR的方法.
- 评估拟议方法在模拟和现实世界临床研究中的性能.
主要方法:
- 提出了一个新的DSR标准,包括成本效益分析.
- 开发了两个时间不变DSR的估计方法:一种使用回归和分类,另一种使用具有替代函数的客观函数放松.
- 在DSR中估计的生物标志物参数的确定的非对称性质.
主要成果:
- 提出的方法在广泛的模拟研究中表现出卓越的性能.
- 这些方法已成功应用于鱼前列腺活跃监测研究 (PASS).
- 估计参数的非对称属性在理论上已经确立.
结论:
- 开发的方法为估计最佳时间不变动态监控规则提供了有效的方法.
- 这些方法为优化患者监测提供了宝贵的工具,通过平衡利益和成本来优化患者监测.
- 这些发现直接适用于临床实践,例如前列腺活性监测研究.
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