在TLR1基因中,一种新的误解化合物异合体变异与对类风湿性关节炎的易感性有关 - 结构视角和功能注释

Usman Pasha1, Kiran Hanif1, Haseeb Nisar1,2

  • 1School of Biochemistry and Biotechnology, University of the Punjab, Lahore, 54590, Pakistan.

Clinical rheumatology
|July 21, 2023
PubMed
概括

研究人员在巴基斯坦类风湿性关节炎 (RA) 患者的收费类受体1 (TLR1) 基因中发现了两种新型遗传变异. 这些变异可能通过改变蛋白质结构和促进炎症来增加对RA的易感性,特别是在家族病例中.

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