在腹腔外科手术后的患者中,性酸酶水平升高的患病率
Claudius Ciecko1, Hayrettin Okut2, Brent Lancaster3
1Office of Research, University of Kansas School of Medicine Wichita, 1010 North Kansas, Wichita, KS, 67214, USA. cciecko@kumc.edu.
Langenbeck's archives of surgery
|July 21, 2023
概括
性酸酶 (ALP) 的升高在减肥手术后很常见,在12个月内影响超过40%的患者. 手术后监测ALP对于早期检测潜在的骨再吸收和肝胆道问题至关重要.
科学领域:
- 腹部外科手术的结果
- 临床化学 临床化学
- 内分泌学 在内分泌学.
背景情况:
- 性酸酶 (ALP) 升高的患病率在腹腔外科手术后是不充分研究的.
- 高的ALP可以表明肝胆道疾病或骨再吸收,导致胆结石和骨质疏松症.
- 早期的ALP监测可以预防并发症并降低医疗保健成本.
研究的目的:
- 为了确定高性酸酶水平在减肥手术后患者的患病率.
主要方法:
- 对230名患者 (≥18岁) 的回顾性研究,这些患者接受了腹腔镜袖子胃切除术 (LSG).
- 测量ALP,BMI,GGT,PTH,calcitriol,calcitonin,维生素D和多维生素补充剂在基线和手术后3,6,12个月.
主要成果:
- 36.1%的患者在3个月后出现ALP升高,42.4%在6个月后出现ALP升高,43.3%在12个月后出现ALP升高 (p<0.001).
- 患者的平均年龄为47岁,平均BMI为44.6.6.
- 记录了6例手术后胆病的病例.
结论:
- 显著比例的减肥手术患者在手术后经历ALP升高.
- 这表明胆囊病理和骨再吸收的患病率高于以前所认为的.
- 对手术后并发症的进一步调查是有必要的,以确定患病率和减轻发病率.
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