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Updated: Jul 22, 2025

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes
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A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes

Published on: May 22, 2018

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使用深度生成模型寻找具有所需性质的蛋白质变体.

Yan Li1, Yinying Yao2,3, Yu Xia1

  • 1School of Information, Yunnan Normal University, Kunming, China.

BMC bioinformatics
|July 21, 2023
PubMed
概括

本研究引入了一个时间变异自编码器 (T-VAE) 模型,通过改善较长的氨基酸序列的表示和产生更相似的蛋白质变异来增强蛋白质工程. 与基线模型相比,T-VAE模型在预测蛋白质适应性和序列身份方面表现出卓越的性能.

关键词:
深度生成模型深度生成模型蛋白质工程是一种蛋白质工程.时间卷积网络的时间卷积网络.变量自动编码器变量自动编码器

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Conserved Binding Sites

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Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
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