rhesus macaque 的社会功能是父亲的,但不是母亲的,被儿子继承:对自闭症的潜在影响
Joseph P Garner1,2, Catherine F Talbot3,4, Laura A Del Rosso3
1Department of Comparative Medicine, Stanford University, 300 Pasteur Drive, Edwards R348, Stanford, CA, 94305-5342, USA. jgarner@stanford.edu.
Molecular autism
|July 21, 2023
概括
rhesus 的社会功能是从父亲继承的,而不是母亲. 这项关于灵长类动物中自闭症特征的父性遗传的研究可能会为人类中自闭症遗传责任提供见解.
科学领域:
- 行为遗传学 行为遗传学
- 灵长类动物的行为
- 量化遗传学 量化遗传学
背景情况:
- 自闭症特征是可以遗传的,并且在人类中持续分布.
- 除了简单的孟德尔遗传之外,父母的起源效应可能会影响自闭症特征模式.
- rhesus 提供了一个研究父母的起源效应的模型,因为它们的繁殖系统产生了半兄弟姐妹.
研究的目的:
- 调查男性 rhesus 的社会功能在父对母遗传的差异性遗传.
- 用灵长类模型评估源代对定量自闭症特征的影响.
- 探索对社会行为变异的遗传贡献.
主要方法:
- 评估了407只雄性 rhesus 的社会功能,使用了伦理学观察和定量自闭症特征尺度.
- 雇佣限制最大概率混合模型来估计遗传变异组件.
- 计算的遗传贡献 (表型变异的比例) 和狭义的遗传性.
主要成果:
- 发现父亲半兄弟姐妹对社会功能有显著的遗传贡献,但母亲半兄弟姐妹却没有.
- 结果在不同的行为测量和分析方法中是一致的.
- 父亲继承效应在完全兄弟姐妹和父亲半兄弟姐妹中是相似的.
结论:
- 雄性 rhesus 的社会功能似乎是从父亲而不是母亲遗传的.
- 这项研究可能会提供关于自闭症遗传责任的性别差异的见解.
- 需要对更大样本进行进一步的研究,包括女性和分子分析.
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