LDL-C/ApoB比率预测了一般人群中心血管和全因死亡率
Li Xiao1, Kerui Zhang1, Fang Wang1
1Center for Cardiovascular Disease, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Guangji Road, Jiangsu, 215002, Suzhou, China.
Lipids in health and disease
|July 21, 2023
概括
LDL-C/ApoB比率 (LAR) 可以预测成人心血管和全因死亡率. 较低的LAR是死亡的独立风险因素,特别是在65岁以上的人群中.
科学领域:
- 心脏病学 心脏病学
- 预防医学 预防医学
- 生物统计学 生物统计学
背景情况:
- 低密度脂蛋白 (LDL) 颗粒大小通常从LDL胆固醇与阿波利波蛋白B比率 (LAR) 推断出来.
- 虽然LAR预测心血管疾病,但其与一般人口死亡率的关联仍然不清楚.
- 这项研究调查了LAR对美国成年人心血管和全因死亡率的预测能力.
研究的目的:
- 为了确定LDL-C/ApoB比率 (LAR) 是否与心血管死亡率有关.
- 评估LAR与一般人群全因死亡率之间的关联.
- 探索潜在的相互作用,如与年龄,在LAR-死亡率的关系.
主要方法:
- 国家健康和营养检查调查 (NHANES) 数据 (2005-2014) 的二次分析.
- 包括12,440名参与者;生存分析使用卡普兰-梅尔曲线和考克斯回归.
- 亚组分析考虑了年龄,性别,并发症和药物使用.
主要成果:
- 较低的LAR与心血管死亡率 (HR=0.304) 和所有原因死亡率 (HR=0.408) 的增加显著相关.
- 观察到与年龄的显著相互作用,65岁以上的个体中更强烈的关联.
- 证实了LAR和死亡风险之间的反向关系.
结论:
- LDL-C/ApoB比率 (LAR) 作为心血管和全因死亡率的独立预测指标.
- LAR的预测价值在老年人中尤为明显.
- 这些发现支持LAR在一般人群风险分层中的有用性.
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