饮食中的黄酸盐摄入量有助于延缓生物衰老过程:来自NHANES数据集的分析
Wenmin Xing1, Wenyan Gao2, Zhenlei Zhao1
1Department of Geriatrics, Zhejiang Provincial Key Laboratory of Geriatrics, Zhejiang Hospital, No. 1229, Gudun Road, 310013, Hangzhou, China.
Journal of translational medicine
|July 21, 2023
概括
饮食中较高的黄酸盐摄入量与较慢的生物衰老有关,特别是在心脏和肝脏. 这表明黄类药物可能有助于降低与心血管和肝脏疾病相关的风险.
科学领域:
- 营养科学 营养科学
- 老年学是一门学科.
- 生物标志物 生物标志物
背景情况:
- 饮食显著影响生物衰老,影响生物年龄 (BA) 和时间年龄 (CA) 之间的差异.
- 调查饮食成分,如黄类素在调节衰老过程中的作用,对于健康的研究至关重要.
研究的目的:
- 为了检查饮食中的黄类消费与全身和特定器官 (心脏,脏,肝脏) 的衰老差异 (∆age) 之间的关联.
- 为了确定哪些黄类子类对生物衰老标志物产生最显著的影响.
主要方法:
- 利用来自2007-2018年美国国家健康和营养检查调查 (NHANES) 3193名美国成年人的数据.
- 通过24小时回忆评估饮食中的黄类素摄入量,并使用循环生物标志物计算生物年龄.
- 采用多重线性回归来分析黄类素摄入量与年龄之间的关系,控制各种因素.
主要成果:
- 增加的黄类药物摄入量与全身,心脏和肝脏的年龄相反相关,表明潜在的抗衰老作用.
- 较高的黄类药物消费与慢性病 (CKD) 患者的衰老增加有关.
- 安东基亚尼丁,异黄和黄显示出与全身和心血管衰老的最强的反向关联.
结论:
- 饮食中的黄似乎促进了生物衰老的减缓,尤其是对心脏和肝脏.
- 这表明在减轻心血管和肝脏疾病的长期风险方面存在潜在的好处.
- 黄类药物对衰老的影响因个体特征和健康状况而异.
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