编码血清素受体2B (HTR2B) 的基因中的rs17619600变异增加了妊娠糖尿病的风险:一个病例对照研究
Juliana Regina Chamlian Zucare Penno1, Daniele Pereira Santos-Bezerra1,2, Ana Mercedes Cavaleiro1
1Laboratório de Carboidratos e Radioimunoensaios (LIM-18), Hospital das Clínicas HCFMUSP, Universidade de São Paulo, Av. Dr. Arnaldo 455, Sala #3321, CEP, 01246-000, Sao Paulo, SP, Brazil.
European journal of medical research
|July 21, 2023
概括
HTR2B基因中的遗传变异与妊娠期糖尿病 (GDM) 有关. 具体来说,SNP rs17619600的小等位基因C通过影响葡萄糖恒温和胰岛素释放,增加了GDM风险.
科学领域:
- 遗传学 遗传学 是一个
- 内分泌学 在内分泌学.
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 孕期糖尿病 (GDM) 源于母亲胰腺β细胞适应妊娠期间胰岛素抵抗增加的失败.
- 血清激素信号传递,特别是通过血清激素受体B (HTR2B),在妊娠期间的β细胞扩张和功能中起着至关重要的作用.
- HTR2B基因的遗传变异可能通过影响这些适应机制来影响对GDM的易感性.
研究的目的:
- 研究HTR2B基因中单核酸多态 (SNPs) 与患妊娠糖尿病 (GDM) 的风险之间的关联.
- 探索特定的HTR2B遗传变异是否会影响葡萄糖平衡和相关的怀孕结果.
主要方法:
- 进行了一项病例控制研究,涉及453名患有GDM的孕妇和443名没有GDM的孕妇.
- 在HTR2B基因中的五个特定SNP (rs4973377,rs765458,rs10187149,rs10194776和rs17619600) 用实时聚合酶链反应进行了基因定型.
主要成果:
- SNP rs17619600的小等位基因C与共同主导和罕见主导模型中GDM风险增加显著相关.
- 对于rs17619600的XC基因型的携带者在口服葡萄糖耐受性测试中表现出更高的血葡萄糖曲线下的面积.
- 研究的SNP与胰岛素使用,母亲体重增加,新生儿体重或产后葡萄糖耐受性之间没有发现显著的关联.
结论:
- 在HTR2B基因中的单核酸多态 rs17619600 涉及影响葡萄糖平衡,可能通过影响胰岛素释放.
- 在rs17619600的小等位基因C的存在是患妊娠糖尿病的危险因素.
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