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Updated: Jul 22, 2025

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通过激活SMAD2/3信号传导,GDF-11降低了胎盘人类胆管性腺激素的表达
Ze Wu1, Lingling Zhang1, Yuanyuan Jia1
1Center for Reproductive Medicine, Henan Key Laboratory of Reproduction and Genetics, The First Affiliated Hospital of Zhengzhou University, 40, Daxue Road, Zhengzhou, 450052, Henan, China.
Cell communication and signaling : CCS
|July 21, 2023
概括
增长分化因子-11 (GDF-11) 减少了胎盘细胞的人类胆性淋巴激素 (hCG) 生产. 这通过ALK4/5-SMAD2/3通道发生,为妊娠调节提供了新的见解.
科学领域:
- 生殖生物学 生殖生物学
- 内分泌学 在内分泌学.
- 细胞信号传递 细胞信号传递
背景情况:
- 人体胆管性腺激素 (hCG) 对于维持怀孕至关重要,异常水平与生殖障碍有关.
- CGB基因编码HCG的独特β亚单元,对其功能至关重要.
- 增长分化因子-11 (GDF-11),TGF-β超级家族成员,存在于胎盘中,并影响 trofhoblast 细胞入侵.
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