鲁) Cl2 - 催化无活性基的三甲基化
Wenhao Su1, Jing Cui1, Runsheng Zeng1
1Key Laboratory of Organic Synthesis of Jiangsu Province College of Chemistry Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, P. R. China.
ChemistryOpen
|July 22, 2023
概括
一种新的Ru(phen) 3Cl2催化反应使未被激活的烯酸的自由基三甲基化成为可能. 这种方法有效地从惰性乳化物中产生含的三甲基化合物,使用Togni试剂和LiCl作为来源.
科学领域:
- 有机化学 有机化学
- 催化剂是一种催化剂.
- 化学 的化学
背景情况:
- 自由基反应对于C-C键的形成至关重要.
- 三甲基化将有价值的CF3和Cl组引入有机分子中.
- 开发有效的方法来使未被激活的烯酸具有功能仍然是一个挑战.
研究的目的:
- 为了研究一种新的Ru(phen) 3Cl2催化自由基三甲基化未激活的烯酸.
- 探索使用替代的8-氨基诺林衍生惰性乳化物作为基质.
- 为了确定反应产品中的来源.
主要方法:
- 使用了一种二 (Ru) 二二二 (Ru) 二二 (Ru) 二二 (Ru) 二二二 (Ru) 二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二
- 使用Togni试剂进行三甲基化.
- 在LiCl.Cl的存在下,与Togni试剂反应的惰性化物.
- 在90°C进行反应.
主要成果:
- 实现了一种新的Ru(phen) 3Cl2催化自由基三甲基化反应.
- 从惰性乳酸盐中成功合成了一系列含的三甲基衍生物.
- 获得的产品具有良好的产量.
- 确认LiCl作为最终产品中的来源.
结论:
- 开发的方法提供了一个有效的途径,以三甲基化化合物.
- 这种反应适用于替代的8 - 氨基诺林衍生惰性乳液.
- 使用Ru(phen) 3Cl2作为催化剂和LiCl作为源对这种转化有效.
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