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Allergic Reactions02:06

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Tumor Immunotherapy01:27

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Antigens Involved in Adaptive Immunity01:26

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An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
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Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
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相关实验视频

Updated: Jul 22, 2025

Antigenic Liposomes for Generation of Disease-specific Antibodies
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针对航空过敏原的类免疫疗法.

Terumi Midoro-Horiuti1, Catherine H Schein2

  • 1From the Department of Pediatrics, Clinical and Experimental Immunology and Infectious Diseases, University of Texas Medical Branch, Texas, Galveston.

Allergy and asthma proceedings
|July 22, 2023
PubMed
概括

对吸入过敏原的类免疫疗法显示出希望,但面临挑战. 新的低过敏性和计算方法可能会通过向B细胞表位体,导致更有效的治疗方法.

科学领域:

  • 过敏和免疫学 过敏和免疫学
  • 免疫疗法研究 免疫疗法研究
  • 计算生物学 计算生物学

背景情况:

  • 过敏特异性免疫疗法 (SIT) 已被用于100多年来治疗过敏.
  • 目前正在进行的研究旨在提高SIT的有效性,并尽量减少不良影响.
  • 了解SIT的机制,包括T细胞调节和抗体类别切换,至关重要.

研究的目的:

  • 审查关于吸入过敏原的类免疫疗法的现有文献.
  • 评估T细胞表皮质在SIT中的潜力.
  • 探索开发有效的基于的免疫疗法的新方法.

主要方法:

  • 在Medline上进行了全面的文献搜索,寻找针对空气过敏原的SIT研究.
  • 对过敏原修饰和治疗途径的现有研究进行分析.
  • 对细胞,动物和临床研究结果的审查.

主要成果:

  • 缺乏IgE结合部位的T细胞表皮质最初有望诱导调节性T细胞 (Treg) 并减少T辅助细胞 (Th) 2.
  • 虽然细胞和动物研究显示成功,但T细胞免疫疗法的临床试验产生了有限的疗效和副作用.
  • 挑战包括高的安慰剂反应率和IgE对T细胞表位的发展.

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Last Updated: Jul 22, 2025

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结论:

  • 低过敏性B细胞表皮质代表了免疫治疗的有前途的新方向.
  • 计算识别方法对于发现和设计新型免疫疗法至关重要.
  • 未来的策略可能涉及通过阻断抗体修改IgE-过敏原结合.