总血清免疫球蛋白E (IgE) 作为在儿童喘中识别过敏喘的有效预测剂
Jianwei Wang1, Yujuan Yang1, Jiayu Cao1
1From the Department of Otolaryngology, Head and Neck Surgery. Yantai Yuhuangding Hospital, Qingdao University, Yantai, China, and.
Allergy and asthma proceedings
|July 22, 2023
概括
总血清免疫球蛋白E (tIgE) 能够有效预测儿童的过敏性喘. 推96.25 IU/mL的tIgE水平用于诊断儿童过敏喘.
科学领域:
- 儿科过敏和免疫学
- 呼吸系统医学 呼吸系统医学
- 诊断生物标志物 诊断生物标志物
背景情况:
- 过敏性喘是最常见的儿童喘类型,通常与血清总免疫球蛋白E (tIgE) 的升高有关.
- tIgE对于诊断儿童过敏喘的预测价值尚未确定.
- 了解tIgE的作用对于准确诊断和治疗儿科喘至关重要.
研究的目的:
- 评估tIgE对儿童过敏喘的预测潜力.
- 在诊断儿童过敏喘时确定tIgE的可靠参考值.
- 为tIgE作为诊断标记物的临床实用性提供证据.
主要方法:
- 从2008年到2018年对儿科喘患者的临床数据和tIgE水平的回顾性分析.
- 利用接收器运行特征 (ROC) 曲线来确定最佳的tIgE截止点和预测值.
- 从2019年开始,在一个独立的队列中使用tIgE截止值验证诊断效率.
主要成果:
- 在2008年和2018年的队列之间观察到tIgE水平的显著下降.
- 在ROC分析中,tIgE截止值为2008年的142.50 IU/mL (AUC=0.864) 和2018年的96.25 IU/mL (AUC=0.835) 的截止值.
- 使用96.25 IU/mL截止值在2019年队列中的验证产生了76.78%的准确性,76.10%的灵敏度和78.03%的特异性.
结论:
- 总血清免疫球蛋白E (tIgE) 是诊断儿童过敏喘的有价值和有效预测剂.
- 诊断儿童过敏喘的推的tIgE切割值为96.25 IU/mL.
- 这一发现支持在常规儿科喘诊断中使用tIgE水平.
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