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抑郁症,焦虑症和神经病症与萨尔科佩尼亚主要指标的因果关系:孟德尔的随机化研究
Yuan Zhang1, Yang Song2, Yuhua Miao1
1The School of Life Sciences of Beijing University of Chinese Medicine, Beijing, China.
International journal of geriatric psychiatry
|July 22, 2023
概括
抑郁症和神经病症因果关系影响肌肉力量和质量,这是萨科佩尼亚的关键指标. 焦虑症与这些肉症标志物没有显著的因果关系,这表明心理健康干预可能有助于预防或管理肉症.
科学领域:
- 遗传学和公共卫生
- 精神病学和老年学 精神病学和老年学
背景情况:
- 观察性研究表明,肉症和精神疾病之间存在联系,但因果关系尚不清楚.
- 标志着肌肉强度和质量低的萨尔科佩尼亚,影响着老年人群.
- 传统研究的局限性阻碍了关于精神病和萨科佩尼亚之间的因果关系的最终结论.
研究的目的:
- 研究抑郁症,焦虑症和神经病症与肌肉力量和肌肉质量之间的因果关系.
- 利用门德尔的随机化 (MR) 分析来克服观察性研究的局限性.
- 探索遗传倾向对精神疾病对萨尔科佩尼亚指标的影响.
主要方法:
- 使用了门德尔的随机化 (MR) 分析.
- 抑郁症,焦虑症和神经病症的遗传变异来源于大规模的生物库和全基因组关联研究.
- 肌肉强度 (手握强度) 和肌肉质量 (尾肌肉质量,身体脂肪百分比) 是主要的结果.
- 反变量加权 (IVW) 方法是主要的分析方法,补充了MR-Egger和加权中位数方法.
主要成果:
- 抑郁症与尾肌瘦质量 (ALM) 减少,手握力低 (LHGS) 和身体脂肪百分比变化有显著的因果关系.
- 神经性表现出与减少ALM,LHGS和改变身体脂肪百分比的显著因果关系.
- 焦虑仅与LHGS有显著的关联,对于ALM或身体脂肪百分比没有发现显著的因果关系.
结论:
- 这项研究提供了抑郁症和神经病症与肌肉强度和质量之间因果关系的证据,这是萨科佩尼亚的关键指标.
- 没有足够的证据支持焦虑和测量到的麻症指标之间存在因果关系.
- 针对心理健康的干预措施,特别是抑郁症和神经病症,可能对预防肉类或减轻老龄化人口中的严重程度至关重要.
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