通过医疗辅助生殖的受孕类型与童年认知之间的关联:丹麦全人口队列研究
1Swedish Institute of Social Research, Stockholm University, Stockholm, Sweden.
European journal of public health
|July 22, 2023
概括
通过医疗辅助生殖 (MAR) 怀孕的儿童表现出不同的认知结果. 虽然子宫内授精 (IUI) 儿童的表现与自发受孕 (SC) 同龄人相似,但辅助生殖技术 (ART) 儿童在调整后得分较低.
科学领域:
- 生殖医学 生殖医学
- 发展心理学 发展心理学
- 儿科 儿科 儿科
背景情况:
- 医疗辅助生殖 (MAR) 涵盖了各种受孕方法.
- 之前的研究表明,在MAR怀孕的儿童中,可比或增强的认知结果.
- 之前的研究缺乏人口层面的数据和MAR类型之间的差异化.
研究的目的:
- 通过不同的 MAR 方法对通过不同的 MAR 方法怀孕的儿童进行认知结果的调查.
- 通过子宫内授精 (IUI) 和辅助生殖技术 (ART) 怀孕的儿童的学业表现与自发受孕 (SC) 的学业表现进行比较.
- 分析人口层面的MAR和认知发展数据.
主要方法:
- 利用了259,608名活产的丹麦国家出生数据 (2006-2009),其中包括13,566名MAR怀孕.
- 在SC,IUI和ART组之间比较标准化小学测试成绩 (2年级/3年级).
- 采用普通最小平方回归,调整出生年,受孕因素和社会人口统计变量.
主要成果:
- 基线分析显示,ART和IUI儿童的测试分数高于SC.
- 在调整后,ART儿童的表现比SC同龄人更差.
- IUI儿童的表现与SC同龄人相比,比ART儿童的表现更好.
结论:
- 马尔类型影响认知结果,IUI显示中性,ART在调整后显示负相关性.
- 父母对MAR类型的选择和生育能力的变化可能解释了最初的差异.
- 社会经济背景显著影响了考试成绩,掩盖了与MAR相关的影响.
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