在2个月的脸皮肤上STAPHYLOCOCCUS AUREUS的殖民化和随后的亚托皮炎之间的关联,在一个潜在的出生队列中
Maria Rasmussen Rinnov1,2, Trine Gerner1, Anne-Sofie Halling1,3
1Department of Dermatology and Allergy.
The British journal of dermatology
|July 22, 2023
概括
2个月后的黄金葡萄球菌殖民在婴儿中更为常见,这些婴儿后来患有亚托皮炎 (AD). 这一发现表明S. aureus在阿尔茨海默氏症早期发展中可能发挥作用.
科学领域:
- 儿科皮肤学 儿科皮肤学
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 黄金葡萄球菌可能会加剧阿托皮性皮肤炎 (AD).
- 黄金杆菌在阿尔茨海默病的发展和严重性中的确切作用尚未完全理解.
研究的目的:
- 为了调查S. aureus在婴儿中殖民的流行情况.
- 为了比较患有AD的婴儿与没有患有AD的婴儿的黄金色杆菌殖民率.
主要方法:
- 450名婴儿的前性出生队列研究.
- 分析0个月和2个月的脸皮肤中的细菌拭子.
- 医生诊断和监测AD发展和严重程度2年.
主要成果:
- 在患有AD的婴儿和没有患有AD的婴儿中,S. aureus殖民在出生时是相似的.
- 在2个月时,S. aureus殖民在后来发展为AD的婴儿中明显更常见 (aHR1.97,P=0.006).
- 没有发现S. aureus殖民化与AD严重程度或发病年龄之间的关联.
结论:
- 在2个月的婴儿中,S. aureus的殖民化更为频繁,这些婴儿随后会患上AD.
- 这项研究表明,S. aureus早期殖民和AD发展之间存在潜在联系.
- 需要进一步的研究,以确定黄金菌是否直接增加AD风险,或者是皮肤屏障问题的结果.
相关概念视频
Development of Immunocompetence
351
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
351
Skin Diseases and Disorders
3.9K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
3.9K
Factors Affecting the Risk of Infection
12.0K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
12.0K


