相关实验视频

Updated: Jul 22, 2025

Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells

Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells

Published on: March 28, 2025

骨髓系衍生抑制细胞通过乳酸代谢通过慢性黄金葡萄球菌感染期间损害CD4+T细胞的反应

Oliver Goldmann¹, Eva Medina²

¹Infection Immunology Research Group, Helmholtz Centre for Infection Research, 38124, Braunschweig, Germany.

Cellular and molecular life sciences : CMLS

|July 22, 2023

概括

骨髓衍生抑制细胞 (MDSC) 通过输出乳酸来阻碍慢性黄球菌感染中的CD4+T细胞免疫力. 这种代谢干扰扰乱了T细胞糖解,促进了持续性感染.

科学领域:

免疫学免疫学免疫学
代谢途径代谢途径
传染性疾病传染性疾病

背景情况:

黄金葡萄球菌慢性感染抵抗宿主清除,需要强大的CD4+T细胞免疫力.
骨髓衍生抑制细胞 (MDSC) 阻碍CD4+ T细胞反应,导致感染的慢性化.
激活的CD4+ T细胞依靠有氧糖解来获得能量,将pyruvate转化为乳酸盐.

研究的目的:

研究MDSC在慢性S. aureus感染期间抑制CD4+T细胞功能的机制.
阐明细胞代谢在MDSC介导的免疫抑制中的作用.

主要方法:

通过分析翻译抑制 (SCENITH) 采用单细胞能量代谢.
分析的重点是MDSC和CD4+T细胞的代谢活性和乳酸分泌.

主要成果:

MDSC表现出高的糖解活性,并出口大量的乳酸盐.
由MDSC衍生的乳酸积累抑制了CD4+T细胞的乳酸去除.
内生乳酸的积累扰乱了CD4+ T细胞的NAD+再生,停止了葡萄糖分解和T细胞功能.

结论:

通过乳酸出口,MDSC通过干扰它们的代谢活动来抑制CD4+ T细胞的反应.
准MDSC新陈代谢可以恢复CD4+T细胞功能,并改善慢性S. aureus感染的结果.

关键词:

CD4+ T 细胞是 CD4+ T 细胞.乳酸盐是一种乳酸盐.骨髓衍生的抑制细胞 (MDSC)在NAD+/NADH的氧化还原过程中,一个丑的女人.黄金葡萄球菌黄金葡萄球菌

更多相关视频

Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice

Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice

Published on: June 22, 2016

A Mouse Model to Assess Innate Immune Response to Staphylococcus aureus Infection

A Mouse Model to Assess Innate Immune Response to Staphylococcus aureus Infection

Published on: February 28, 2019

相关概念视频

Defense Against Bacterial Pathogens

Defense Against Bacterial Pathogens

The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...

Regulation of Hematopoietic Stem Cells

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...