kindlin-2notch1

Yuechao Dong1, Guixing Ma2, Xiaoting Hou1

  • 1Department of Biochemistry, School of Medicine, Southern University of Science and Technology, Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Key University Laboratory of Metabolism and Health of Guangdong, Southern University of Science and Technology, Shenzhen, 518055, China.

概括

kindlin-2对生理血管生成至关重要,这是对发育至关重要的过程. 它的缺乏会损害血管形成,强调Kindlin-2作为糖尿病视网膜病变等疾病的治疗点.

相关概念视频

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Regulation of Angiogenesis and Blood Supply

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Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
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Role Of Notch Signalling In Intestinal Stem Cell Renewal

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Intracellular Signaling Affects Focal Adhesions

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PI3K/mTOR/AKT Signaling Pathway

The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a...
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