不一致的生物和时间年龄:对认知衰退和脆弱性的影响
C Elizabeth Shaaban1, Caterina Rosano1, Xiaonan Zhu1
1Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
概括
具有不一致的生物年龄和时间年龄的老年人表现出不同的认知和身体功能. 这一发现有助于识别更高风险的个体或那些对有针对性的干预更有弹性的人.
科学领域:
- 老年学是一门学科.
- 衰老研究研究 衰老研究
- 衰老的生物标志物
背景情况:
- 老年人表现出认知和身体功能的变化,基于他们的生物年龄 (BA) 和时间年龄 (CA) 之间的不一致.
- 了解这种不一致对于评估老龄化人口的功能轨迹至关重要.
研究的目的:
- 研究老年人不一致的生物和时间年龄与认知和身体功能之间的关联.
- 开发基于BA-CA不一致性的临床可访问的风险分层组.
主要方法:
- 利用了来自健康,衰老和身体组成研究 (N=2,458) 的数据,对BA和CA进行了基于中位数的分类.
- 采用联合模型来评估BA-CA组 (年轻人,过早衰老,老年人,有弹性) 与认知 (3MS,DSST) 之间的关系,以及10年来脆弱的结果.
主要成果:
- 与"年轻"组相比",过早衰老"组 (更高的BA,更年轻的CA) 的认知和身体功能表现较差.
- "弹性"组 (低BA,旧CA) 比"老"组 (高BA,旧CA) 显示出更好的身体功能.
- 在比较组之间没有观察到随时间变化结果的显著差异.
结论:
- 不一致的生物和时间年龄识别出不同的老年人群体,具有不同的认知和身体功能衰退或保护.
- 这些发现支持使用BA-CA不一致性用于临床环境中的风险分层.
- 这项研究强调了评估生物年龄的重要性,而不仅仅是时间年龄,为了全面了解衰老.
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