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在盆腔放射治疗后二十年的低度肠炎症
Sravani Devarakonda1, Annika Thorsell2, Per Hedenström3
1Division of Clinical Cancer Epidemiology, Department of Oncology, Institute of Clinical Sciences, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
EBioMedicine
|July 22, 2023
概括
盆腔放射治疗可能会导致慢性肠道问题,原因是持续的低级炎症和削弱的粘液屏障,挑战了以前关于放射治疗后愈合的假设.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
背景情况:
- 盆腔放射疗法有效治疗癌症,但可能导致长期的肠道并发症.
- 放射治疗后这些慢性肠道症状的根本原因尚不清楚.
- 关于在盆腔辐射后晚期出现慢性炎症的存在,目前仍在进行辩论.
研究的目的:
- 调查盆腔癌幸存者的肠粘膜中可能存在慢性炎症的可能性.
- 了解骨盆放射治疗后慢性肠道症状的病理生理学.
主要方法:
- 从24名癌症幸存者 (放射治疗后2-20年) 和4名使用质谱和mRNA测序的对照对粘膜活检的蛋白质组和转录组分析.
- 通过流细胞计对免疫细胞群的分析.
- 评估粘液层完整性和细菌透,使用透性测试和16S rRNA检测.
主要成果:
- 942种蛋白质在暴露于高剂量和低剂量辐射的粘膜中的差异表达.
- 有证据表明慢性低度炎症与中性粒细胞活性,通过转录组数据和流细胞计验证.
- 观察到一个受损的粘液屏障与细菌透.
结论:
- 结果挑战了辐射诱导的肠道炎症会消失或变为纤维化的概念,而不会发展为慢性炎症.
- 研究结果表明,在盆腔放射治疗的后期阶段存在慢性炎症成分.
- 这项研究为开发新的策略提供了基础,以管理癌症幸存者的慢性肠道症状.
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