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针对Clostridium perfringens抗原开发的超免疫蛋黄抗体可以预防死性肠炎

D Goo¹, U D Gadde², W K Kim¹

¹Department of Poultry Science, University of Georgia, Athens, GA, USA.

Poultry science

|July 22, 2023

概括

禽类的死肠炎可以通过使用高免疫卵黄抗体 (IgY) 进行被动免疫治疗来管理. 这项研究表明,针对Clostridium perfringens毒素的IgY有效地保护肉免受死性肠炎的侵害.

科学领域:

禽畜科学禽畜科学禽畜科学
免疫学免疫学免疫学
兽医医学兽医医学兽医医学

背景情况:

由Clostridium perfringens引起的死肠炎 (NE) 给家禽业带来了重大的经济挑战.
越来越多的抗生素使用限制需要替代NE控制策略.

研究的目的:

评估使用超免疫卵黄免疫球蛋白Y (IgY) 对肉中Clostridium perfringens诱导的死肠炎的被动免疫的疗效.

主要方法:

超免疫IgY是由用特定的C. perfringens抗原 (α-毒素,NetB,ET) 免疫产生的.
喷雾干燥的含有IgY的卵粉被施用给受到Eimeria maxima和C. perfringens的 brojler.
通过监测体重增加,病变评分,血清毒素水平和肠道透性来评估保护作用.

主要成果:

食IgY向NE B类毒素 (NetB) 和延长因子-Tu (ET) 显著改善了体重增加,并降低了NE损伤得分和血清NetB水平.
在体外试验证实了IgY对NetB的作用,降低了肝细胞细胞毒性.
针对C. perfringens和Eimeria抗原的IgY混合物表现出与对照组相比较的性能和肠道健康.

结论:

用特定的IgY抗体进行被动免疫,为控制家禽死肠炎提供了抗生素的可行替代方案.
用饮食IgY准关键的C. perfringens抗原,如NetB和ET,可以有效地减轻与NE相关的损害和经济损失.

关键词:

克洛斯特里 (Clostridium perfringensens) 是一种有毒的植物.brojler 肉肉是一个蛋黄免疫球蛋白Y 蛋黄免疫球蛋白Y 死亡性肠炎 (necrotic enteritis) 是一个疾病.死亡性肠炎B类毒素类似毒素

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