由非线性麦克斯韦尔模型描述的原纤维拉伸反应
Martin Handelshauser1, You-Rong Chiang2, Martina Marchetti-Deschmann3
1Institute of Lightweight Design and Structural Biomechanics, TU Wien, 1060, Vienna, Austria; Institute of Chemical Technologies and Analytics, TU Wien, 1060, Vienna, Austria.
概括
这项研究使用非线性风湿学麦克斯韦模型来模拟原纤维的机制. 降低水分增加了纤维的纤维.
科学领域:
- 生物材料科学 生物材料科学
- 机械生物学 机械生物学
- 软物质物理学 软物质物理学
背景情况:
- 原纤维是重要的结构部件,为组织提供机械完整性.
- 它们的机械性能,包括刚性和性,受到水化和变形机制的影响.
- 了解原纤维的粘性弹性对于组织工程和理解疾病至关重要.
研究的目的:
- 应用一个非线性风湿学麦克斯韦模型来量化个体原纤维的粘弹性行为.
- 研究水分水平对原纤维的机械性能的影响.
- 探索应变率,水合和原纤维细胞机械反应之间的关系.
主要方法:
- 将非线性学麦克斯韦模型与实验性拉伸应力时间数据相匹配.
- 使用原子力显微镜 (AFM) 从以前对水合和部分脱水的原纤维的研究中获得的数据.
- 分析引力模量和粘度的衍生值作为水合和拉伸速率的函数.
主要成果:
- 原纤维的衍生拉伸模量随着水分的减少而显著增加.
- 粘度仅受到水化水平的边际影响.
- 粘度显示出对应变速率的依赖性,表明在低应变速率下潜在的厚性otropic行为.
结论:
- 非线性风湿学麦克斯韦模型有效地描述了原纤维的粘性弹性.
- 补水是影响原纤维硬度的关键因素.
- 原纤维可能会表现出粗性质,特别是在较低的应变速率下,影响它们的动态机械反应.
相关概念视频
Cell-matrix's Response to Mechanical Forces
2.7K
In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue.
Anchoring junctions mechanically attach a cell to the...
Anchoring junctions mechanically attach a cell to the...
2.7K
Relation between Poisson's ratio, Modulus of Elasticity and Modulus of Rigidity
296
Deformation occurs in axial and transverse directions when an axial load is applied to a slender bar. This deformation impacts the cubic element within the bar, transforming it into either a rectangular parallelepiped or a rhombus, contingent on its orientation. This transformation process induces shearing strain. Axial loading elicits both shearing and normal strains. Applying an axial load instigates equal normal and shearing stresses on elements oriented at a 45° angle to the load axis.
296
Hooke's Law
476
Hooke's law, a pivotal principle in material science, establishes that the strain a material undergoes is directly proportional to the applied stress, defined by a factor called the modulus of elasticity or Young's modulus.
476
Fibril-associated Collagen
2.6K
Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
2.6K
Members Made of Elastoplastic Material
124
The behavior of elastoplastic materials under bending stresses, particularly in structural members with rectangular cross-sections, is crucial for predicting material responses and understanding failure modes. Initially, when a bending moment is applied, the stress distribution across the section follows Hooke's Law and is linear and elastic. This distribution means the stress increases from the neutral axis to the maximum at the outer fibers, up to the elastic limit.
As the bending moment...
As the bending moment...
124
Flexural Stress
328
When analyzing bending in symmetric members, it's crucial to understand how stresses distribute when subjected to bending moments. This stress distribution is effectively described by applying fundamental mechanics and material science principles, particularly Hooke's Law for elastic materials.
Hooke's Law states that within the material's elastic limits, stress is directly proportional to strain. In a member experiencing a bending moment, the strain at any point is relative to...
Hooke's Law states that within the material's elastic limits, stress is directly proportional to strain. In a member experiencing a bending moment, the strain at any point is relative to...
328


