月经周期和使用荷尔蒙避孕药对MS症状波动的影响:试点研究
Helga Taylor1, Saleh Alhasan2, Maha Saleem2
1UCSF Weill Institute for the Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, United States.
Multiple sclerosis and related disorders
|July 22, 2023
概括
连续口服避孕药 (OCs) 可以减少多发性硬化症 (MS) 的女性的症状波动. 这项试点研究发现,与其他组相比,连续使用OC的用户的疲劳和日常麻烦变化较小.
科学领域:
- 神经学 神经学
- 妇科 妇科医生 妇科
- 药理学 药理学是指药理学的学科.
背景情况:
- 患有多发性硬化症 (MS) 的女性经常经历与她们的月经周期相关的症状波动.
- 持续口服避孕药 (OCs) 被假设通过保持一致的激素水平来减轻这些波动.
研究的目的:
- 为了前性地评估MS的女性神经系统和泛型症状是否与月经周期阶段有所不同.
- 为了确定是否使用的避孕类型会影响症状的变化.
主要方法:
- 一项两中心试点研究,涉及患有多发性硬化症的女性和定期的月经周期.
- 参与者跟踪了周期,并完成了长达6个月的症状调查,按避孕类型分类:连续性避孕,周期性避孕,激素宫内避孕器或没有激素避孕.
- 分析了47名参与者的数据.
主要成果:
- 疲劳在月经前期低于内生循环参与者 (荷尔蒙IUD和没有用户) 的黄质期.
- 与内生自行车女性和周期性OC用户相比,连续OC用户的疲劳 (MFIS) 和日常麻烦的变化明显较小.
- 在内源性骑自行车的参与者中没有观察到与月经周期相关的确切症状波动.
结论:
- 在内生自行车参与者中,症状严重程度与月经周期不一致而波动.
- 持续使用OC与疲劳和日常麻烦的变化减少有关.
- 需要对更大的队列进行进一步的研究,以确认是否可以选择避孕措施来管理MS女性的症状波动.
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