血静贴片具有超强化的机械性能,可以有效地粘附于湿表面
Yuting Zheng1, Kaavian Shariati2, Mahsa Ghovvati3
1Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Biomaterials
|July 22, 2023
概括
开发了一种新的水凝生物粘合剂,用于控制内脏器官的创伤性出血. 这种先进的材料具有卓越的粘附性,机械强度和生物相容性,性能优于目前用于伤口密封和静血的治疗方法.
科学领域:
- 生物材料科学 生物材料科学
- 再生医学是一种再生医学.
- 手术创新 在外科创新.
背景情况:
- 从内部器官的创伤性出血构成了重大的临床挑战.
- 现有的生物粘合剂有其局限性,包括不良的血液兼容性,对湿组织的粘合力较弱,以及机械性能不足.
研究的目的:
- 设计一种准备使用的静血生物粘合剂,具有增强的机械性能,强大的湿组织粘附性和高效的出血控制.
- 克服当前手术密封剂的局限性,改善创伤护理中的患者结果.
主要方法:
- 使用N-hydroxysuccinimide (NHS) 结合的酸 (Alg-NHS),聚乙烯糖 (PEGDA),酸 (TA) 和Fe3+离子制造水凝.
- 描述水凝的特性,包括弹性,性和粘附于湿组织.
- 与商业标准相比,体外和体内对生物相容性和静血疗效的评估.
主要成果:
- 工程水凝表现出超强化的机械性能 (弹性>900%,性>4600kJ/m3) 和耐疲劳性.
- 在几秒钟内通过双粘合剂部分 (以鱼为灵感的醇/甲基醇和NHS) 实现了对湿组织 (>400 kPa) 的坚固粘附.
- 在体外和体内表现出卓越的静血疗效和出色的生物相容性,优于Surgicel®.
结论:
- 开发的水凝生物粘合剂为控制创伤性出血提供了有前途的解决方案,其粘合力和机械完整性得到了改善.
- 创新的设计策略解决了现有生物粘合剂的关键局限性,为临床转化铺平了道路.
- 这种先进的生物材料有可能彻底改变手术程序和创伤管理.
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