骨髓/淋巴瘤新生体与FGFR1重组呈现多细胞血症 维拉和T细胞急性淋巴细胞白血病
Lisa M Marinelli1, Joshua T Romain2, William Ehman3
1Department of Pathology and Area Laboratory Services, Brooke Army Medical Center, 3551 Roger Brooke Dr, Fort Sam Houston, TX, USA, 78234.
Cancer genetics
|July 22, 2023
概括
这项研究详细介绍了一种罕见的骨髓状/淋巴状瘤与纤维细胞生长因子1重组 (MLN-FGFR1) 和ASXL1突变. 它还在这个具有挑战性的血液性恶性瘤中确定了新的HDAC4和CHEK2变体.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
背景情况:
- 带有纤维细胞生长因子1重组 (MLN-FGFR1) 的髓状/淋巴状瘤是罕见的血液性恶性瘤.
- 诊断通常需要整合形态学,免疫类型,细胞遗传学和分子发现.
相关概念视频
01:15Differentiation of Common Myeloid Progenitor Cells
3.2K
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
3.2K
01:27Disorders of Leukocytes
983
Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
983