时间利基进化的基因组基础在一个白天动物动物的进化
Rose Richardson1, Charles Y Feigin2, Beatriz Bano-Otalora3
1Centre for Biological Timing, Faculty of Biology Medicine and Health, University of Manchester, Manchester M13 9PT, UK; Division of Neuroscience, Faculty of Biology Medicine and Health, University of Manchester, Manchester M13 9PT, UK.
Current biology : CB
|July 22, 2023
概括
非洲条纹老鼠从夜间活动转变为白天活动,经历了显著的昼夜组织变化. 这种转变涉及其视觉系统的适应,特别是杆光传导通路.
科学领域:
- 进化生物学是进化的生物学.
- 基因组学就是基因组学.
- 时间生物学 时间生物学
背景情况:
- 活动模式对于动物生理学和环境相互作用至关重要.
- 脊椎动物进化过程中,神经活动的变化是常见的,但是基因组的基础是不太了解的.
研究的目的:
- 为了研究非洲条纹老鼠中迪尔过渡的基因组基础.
- 为了识别与从夜间活动转变为白天活动相关的分子变异和选择压力.
主要方法:
- 为*Rhabdomys pumilio*生成染色体级的基因组组合.
- 转录组分析以评估外围组织中的每日节奏.
- 与相关的动物物种进行比较的基因组学.
- 电网红学仪测量以评估视觉反应.
主要成果:
- 在条纹小鼠中,切换到白天活动与外围组织节律与光:黑暗周期和中央生理时钟的重新调整有关.
- 对比基因组学揭示了条纹小鼠的杆光传导途径中的基因的放松净化选择.
- 与夜间动物相比,条纹小鼠在暗光视觉反应中表现出功能上的差异.
结论:
- 非洲条纹老鼠在其昼夜组织中发生了实质性的变化.
- 视觉系统,特别是杆光传导通路,在这个时间利基转移期间似乎是选择的主要目标.
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