相关实验视频

Updated: Jul 22, 2025

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology
14:57

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology

Published on: March 23, 2011

94.2K

由Wwl70诱导的ABHD6抑制减轻了APPswe/PS1dE9小鼠的记忆缺陷和病理表型

Zhiwei Xue1, Lei Ye1, Jianwei Ge1

  • 1Department of Neurology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China; State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases, Nanjing University, Nanjing, China; Jiangsu Key Laboratory for Molecular Medicine, Medical School of Nanjing University, Nanjing, Jiangsu, China; Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, Jiangsu, China; Nanjing Neuropsychiatry Clinic Medical Center, Nanjing, Jiangsu, China.

Pharmacological research
|July 22, 2023
PubMed
概括

在阿尔茨海默病 (AD) 模型中抑制ABHD6改善了突触功能和记忆. 这表明ABHD6抑制是AD治疗的有前途的治疗策略.

关键词:
这是一个ABHD6HD6的数字.AM251 (PubChem CID: 2125) 是一家在美国的公司.AM630 (PubChem CID: 4302963) 是一家在美国的公司.阿尔茨海默氏症的疾病是阿尔茨海默氏症.粉样蛋白-β 是一种蛋白质.Aβ(142) (PubChem CID: 57339251) 这是一项研究.记忆功能 记忆功能 记忆功能微质细胞中的微质细胞突触性可塑性 突触性可塑性Wwl70 (PubChem CID: 17759121) 这是一个非常好的产品.

更多相关视频

Analysis of Learning and Memory Ability in an Alzheimer's Disease Mouse Model using the Morris Water Maze07:07

Analysis of Learning and Memory Ability in an Alzheimer's Disease Mouse Model using the Morris Water Maze

Published on: October 29, 2019

19.2K
The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents09:01

The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents

Published on: July 8, 2015

12.6K

相关概念视频

Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
525
Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
219