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Updated: Jul 22, 2025

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用天然化合物andrographolide降解MK2:一种新的抗炎疗法模式

Quy T N Tran1, Phyllis X L Gan2, Wupeng Liao3

  • 1Department of Pharmacology, Yong Loo Lin School of Medicine, National University Health System, 117600, Singapore; Department of Pharmacy, Faculty of Science, National University of Singapore, 117543, Singapore; Drug Discovery and Optimization Platform (DDOP), Yong Loo Lin School of Medicine, National University Health System, 117600, Singapore.

Pharmacological research
|July 22, 2023
PubMed
概括

安德罗格拉福利德 (AG) 通过降解MK2蛋白来抑制炎症,MK2蛋白是p38中基因激活蛋白激酶 (MAPK) 途径的关键组成部分. 这种新的机制比目前的抑制剂提供了更持久的抗炎作用.

关键词:
膜细胞巨细胞.安德罗格拉福利德 (Andrographolide) 是一种色蛋白质.在MK2MK2MK2MK2蛋白质酶体是一种蛋白质酶体.小分子降解剂 降解剂三甲罗林 (Tristetraprolin) 是一种三甲罗林 (Tristetraprolin) 的一种化合物.

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