在多个尿样和胎盘DNA甲基化中评估产前暴露于triclosan
Paulina Jedynak1, Lucile Broséus1, Jörg Tost2
1University Grenoble Alpes, Inserm U 1209, CNRS UMR 5309, Team of Environmental Epidemiology applied to Development and Respiratory Health, Institute for Advanced Biosciences, Grenoble, France.
Environmental pollution (Barking, Essex : 1987)
|July 22, 2023
概括
孕产妇暴露于 triclosan 与胎盘 DNA 甲基化变化有关,特别是在女性胎儿. 这项研究证实了先前的发现,并强调了对印记基因的潜在影响,表明胎盘组织异质性可能起作用.
科学领域:
- 环境表观遗传学环境表观遗传学
- 生殖毒理学 生殖毒理学
- 人的胎盘发育 人的胎盘发育
背景情况:
- 广泛暴露于合成的 triclosan 引起了人们对其发育影响的担忧.
- 之前的研究表明,在男性胎儿中,母亲暴露于 triclosan 和胎盘 DNA 甲基化之间存在联系.
- 对这些表观遗传关联的进一步验证和性别特定调查的需要至关重要.
研究的目的:
- 在一组男性和女性胎儿中,研究母亲尿液中的三香度与胎盘DNA甲基化之间的关联.
- 验证和扩展以前关于三桑表观遗传效应的发现.
- 探索潜在的性别特异性差异和胎盘组织异质性的调解.
主要方法:
- 在SEPAGES队列中的395名妇女的样本中测量了母亲尿液中的三桑水平.
- 使用Infinium Methylation EPIC阵列评估了胎盘DNA甲基化.
- 进行了候选和全表观基因组关联研究,分析按胎儿性别分层.
主要成果:
- 该研究在整体队列中证实了18个与triclosan相关的基因.
- 观察到显著的性别相关联:女性有72个基因,男性有3个基因.
- 几个已识别的CpG位于印记基因中,并确定了胎盘组织异质性作为调解者.
结论:
- 孕产妇暴露于 triclosan 与胎盘 DNA 甲基化的显著改变有关,在女性胎儿中观察到的效果更强.
- 这些发现加强了人们对环境通过表观遗传机制影响胎儿发育的担忧.
- 需要进一步的研究,以了解这些表观遗传变化的长期影响.
关键词:
通过DNA甲基化.表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.印记的基因被打印出来.无极甲基化EPIC EPIC 公司胎盘 胎盘 胎盘 胎盘聚合的尿样采集了尿样.三克洛桑是一种三克洛桑.更多相关视频
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