过高甘油三血症高血压和非酒精性脂肪肝疾病的发展和解决:一个队列研究
Yiying Wang1, Lijie Kong1, Chaojie Ye1
1Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
过高甘油血型的hyperapoB表型增加了非酒精性脂肪肝疾病 (NAFLD) 的发病率,并降低了中国成年人的解决方案. 这种不良脂蛋白形状是NAFLD风险的关键指标.
科学领域:
- 心血管和代谢疾病 心血管和代谢疾病
- 肝病学 肝病学是一种肝病学.
- 脂质学 脂质学是指脂质学.
背景情况:
- 过高甘油三性过高apoB是一种与心血管风险相关的不良脂蛋白表型.
- 非酒精性脂肪肝 (NAFLD) 是一个日益严重的公共卫生问题,具有复杂的危险因素.
- 过高甘油三血性超和NAFLD发病率/解决之间的关联需要进一步调查.
研究的目的:
- 调查超高甘油三血性超和非酒精性脂肪肝疾病 (NAFLD) 的发生率之间的关联.
- 为了检查过高甘油三血性超和NAFLD的解决之间的关系.
- 评估这种脂蛋白表型在中国成年人群中的预测价值.
主要方法:
- 一项前性队列研究,涉及9019名40岁及以上的中国参与者.
- 使用后勤回归模型分析NAFLD发病率和解决方案的几率比率 (ORs).
- 随访时间的中位数为4.3年,调整了人口统计学,生活方式和代谢因素.
主要成果:
- 患有过高甘油三血症的参与者显示,NAFLD发病率的几率明显更高 (OR:2.75),NAFLD解决率更低 (OR:0.57).
- 个别的脂质参数,如高甘油三和高阿波蛋白B (ApoB) 独立与NAFLD发病率相关.
- 甘油三水平也独立地与NAFLD解决有关.
结论:
- 过高甘油血性超高ABOB表型是NAFLD发病率的显著风险因素,也是中国成年人中NAFLD解决的负面预测因素.
- 这些关联在各种各样的子组中保持一致,突出显示了表型的强度.
- 过高甘油三血性过高apoB是NAFLD预防和管理的有价值的临床标志物.
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