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在1岁的婴儿中,果仁过敏的发生率和敏感性
Tim Brettig1, Victoria X Soriano2, Shyamali C Dharmage3
1Population Allergy Group, Murdoch Children's Research Institute, Parkville, Melbourne, Victoria, Australia; Centre for Food and Allergy Research, Murdoch Children's Research Institute, Parkville, Melbourne, Victoria, Australia.
概括
果仁过敏影响1.49%的澳大利亚婴儿,湿疹和花生过敏增加了风险. 在12个月之前早期引入果没有显示出与过敏发展的关联.
科学领域:
- 儿科过敏和免疫学
- 流行病学 流行病学
- 临床营养学 临床营养学
背景情况:
- 果仁过敏是澳大利亚普遍存在的树木坚果过敏症,但人口层面上关于患病率和风险因素的数据很少.
- 对于婴儿果过敏的特定风险因素和患病率的了解有限.
- 这项研究解决了对澳大利亚年轻人口的果仁过敏数据的需求.
研究的目的:
- 为了确定12个月大的婴儿中果仁敏感和过敏的流行率.
- 在这个年龄组中确定与果仁过敏相关的重大风险因素.
主要方法:
- 利用来自澳大利亚墨尔本人口 EarlyNuts 队列的数据.
- 婴儿接受了皮肤刺伤测试 (SPT) 寻找果仁,结果呈阳性,随后有食物挑战.
- 调查问卷收集了人口统计信息和潜在的过敏风险因素,对人口代表性进行了加权分析.
主要成果:
- 在1933名婴儿中观察到1.49% (95% CI,0.91-2.44) 的果仁过敏患病率.
- 在第一年患有湿疹 (aOR=5.75) 或花生过敏 (aOR=19.30) 的婴儿患有果仁过敏的几率明显更高.
- 25%的参与者在12个月前引入,没有发现引入时间和过敏发展之间的关联.
结论:
- 这是第一个基于人口的婴儿队列研究,详细介绍了果仁过敏的流行率和危险因素.
- 湿疹和先前的花生过敏是发展果仁过敏的确诊危险因素.
- 早期介绍南瓜的低率表明,推迟实施婴儿过敏原养指南.
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