在早期出现的双相情绪障碍中与药物使用相关的神经成像变化:更新的综述
Parya Valizadeh1, Giulia Cattarinussi2, Fabio Sambataro2
1School of Medicine, Tehran University of Medical Science, Tehran, Iran; Neuroscience Research Group (NRG), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
Journal of affective disorders
|July 22, 2023
概括
抗精神病药物和情绪稳定剂等药物可能会在儿科双极性障碍 (PBD) 中使大脑结构和功能正常化. 本综述审查了对PBD治疗对杏仁体和前额叶皮层的影响的神经成像研究.
科学领域:
- 神经科学是一个神经科学.
- 儿童精神病学 儿童精神病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 儿科双相情感障碍 (PBD) 是一种严重的心理健康状况,影响儿童和青少年.
- 神经成像研究显示,PBD与桃体和前额叶皮层等大脑区域的变化有关.
- 人们担心PBD治疗对发育中的大脑的影响.
研究的目的:
- 审查现有的神经成像研究对常见的PBD药物的影响.
- 调查情绪稳定剂,抗精神病药物和抗药物如何影响PBD中神经成像发现.
- 了解药理干预对儿科双相情感障碍中大脑结构和功能的影响.
主要方法:
- 在PubMed,Scopus和Web of Science数据库中的系统文献搜索.
- 包括使用结构性MRI (sMRI),功能性MRI (fMRI) 和扩散张力成像 (DTI) 的研究.
- 对18项调查药物对PBD神经成像效应的研究进行分析.
主要成果:
- 药物效应主要在前额叶皮和杏仁核中观察到.
- 大多数研究表明,大脑结构和功能趋于正常化.
- 由于方法上的差异,神经成像发现在不同研究中存在显著差异.
结论:
- 抗精神病药物和情绪稳定剂在调节PBD中神经成像结果方面显示出潜力.
- 这些药物可能有助于正常化大脑结构和关键情绪调节区域的功能.
- 需要使用强大的方法进行进一步的研究来证实这些发现.
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