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Updated: Jul 22, 2025

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
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在新生大鼠中,新生大鼠具有缺氧-缺血性白质损伤的寡基基因发生的动态变化

Qing Lin1, Ling Lin2, Li Li3

  • 1Fujian Provincial Key Laboratory of Brain Aging and Neurodegenerative Diseases, Fujian Medical University, Fuzhou, China; Laboratory of Clinical Applied Anatomy, Department of Human Anatomy, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China.

Brain research
|July 22, 2023
PubMed
概括

新生小鼠的低毒性-缺血性白质损伤 (WMI) 长期扰乱了寡细胞的发育. 在治疗早产脑损伤方面,早期促进寡类细胞前体细胞 (OPC) 增殖可能是关键.

关键词:
缺氧缺血症是什么意思新生小鼠新生小鼠.有机基生成 (Oligodendrogenesis) 是一种白质损伤的伤害是白质的伤害.

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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