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Updated: Jul 22, 2025

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在通过与替代DNA结构的结合来维持基因组稳定性中,PARP1的多方面的作用

Natalie Laspata1, Daniela Muoio2, Elise Fouquerel2

  • 1UPMC Hillman Cancer Center, University of Pittsburgh Cancer Institute, Department of Pharmacology and Chemical Biology, Pittsburgh, PA 15232, USA; Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

Journal of molecular biology
|July 22, 2023
PubMed
概括

聚 (ADP-ribose) 聚合酶1 (PARP1) 蛋白与替代DNA结构结合并有助于解决,防止基因组不稳定性和相关疾病. 这篇评论详细介绍了PARP1的细节.

关键词:
在G-四重复合体中.PARP1 的第一部分.在R-Loop中使用.发针和十字架形状的停滞的叉子停滞的叉子

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